Today in London, some of the biggest players in global health committed a renewed and intensified focus on neglected tropical diseases, a group of diseases affecting the world’s poorest people. One in six people, or 1.4 billion people around the world, have an NTD and one in three people are at risk. Though NTDs don’t always kill, they cause disabilities, making it difficult or impossible for children to attend school and for adults to work and support their families.
The international, cross-sector meeting marked collaboration between governments, the World Health Organization (WHO), the World Bank, the Gates Foundation, pharmaceutical companies, and global health NGOs. It is also an historic pledge that brings new promise and hope to those affected and advances science and health for all. Sir Andrew Witty, CEO, GlaxoSmithKline noted that the variety of different commitments across sectors demonstrates these collaborations want to “travel far” to end NTDs. “If you want to travel fast, travel alone. If you want to travel far, travel as a group,” he said, quoting an African proverb.
Making best use of existing tools to combat diseases will only get us part of the way. The 2020 goals are achievable only with new tools—including drugs, vaccines and diagnostics. Nine of the ten targeted NTDs required new investment in research and development.
To take just one example, visceral leishmaniasis is almost always fatal if untreated, and there are approximately 500,000 cases each year, largely in South Asia and the horn of Africa. The cost of treatment plus loss of income due to one case of VL represents at least 50% of the average spent per family member per year. What’s worse, more than half of people who seek treatment must do so more than once to cure the disease. Available therapies are sometimes toxic or ineffective. New, more effective medicines are needed, at a lower cost, and with fewer side effects.
A consortium project led by Drugs for Neglected Diseases Initiative, in partnership with California-based OneWorld Health and TDR, WHO’s Special Programme for Research and Training in Tropical Diseases, aims to establishing and implementing new treatment modalities as successful tools to control and support the elimination of VL in most endemic regions of South Asia. California-based pharmaceutical company Gilead is investing in further research to reduce the cost of treatment.
In addition to narrowing funding gaps, new licensing or collaboration agreements have opened up “libraries” of scientific knowledge and research compounds. As a result, one pharmaceutical company recently shared 300 compounds with a lab in Argentina to conduct research on Chagas, an NTD common in rural parts of Central and South America, and sometimes found in poor parts of the United States.
Something as ambitious as this takes commitment from the public, private and philanthropic sectors, but the public must become increasingly engaged as well. The names of diseases like visceral leishmaniasis don’t exactly roll off the tongue of those of us in developed countries, and fewer people could tell you why the condition is so devastating. To increase public awareness and advocacy of NTDs, the Sabin Vaccine Institute-based Global Network’s new END7 campaign aims to end seven of the most common NTDs by 2020. It’s going to take an increased effort on all our parts to make NTDs a thing of the past.