On May 6, the National Institutes of Health (NIH) will open national enrollment for the All of Us Research Program, an important milestone in advancing individualized prevention, treatment and care. People age 18 and older, regardless of health status, will be able to enroll. An online program featuring NIH Director Dr. Francis Collins, and community events in seven cities will take place on May 6. Volunteers will join more than 25,000 participants already enrolled in All of Us as part of a yearlong beta test to prepare for the program’s national launch. The goal is to enroll 1 million or more volunteers and oversample communities that have been underrepresented in research to make the program the largest, most diverse resource of its kind. Collected data will be broadly accessible to researchers to support thousands of studies. For more information, visit www.allofus.nih.gov.